加入收藏
百奥莱博公司客服电话百奥莱博QQ百奥莱博QQ百奥莱博QQ
百奥莱博公司微信服务号

产品目录

PI3 Kinase p110 Alpha/PIK3CA抗体图片
产品货号:
Z36714
中文名称:
PI3 Kinase p110 Alpha/PIK3CA抗体
英文名称:
Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody
指标别名p110 alpha;PI3 kinase subunit alpha;PI3K;PI3K alpha;PI3K p110(alpha);PIK3CA;PtdIns 3 kinase subunit alpha
克隆性Monoclonal
检验物种human
应用范围WB,ICC/IF
基因名称PIK3CA
抗体来源Rabbit
抗体类型IgG
免疫原A synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol),PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns (4,5) P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3).PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane,including AKT1 and PDPK1,activating signaling cascades involved in cell growth,survival,proliferation,motility and morphology.Participates in cellular signaling in response to various growth factors.
实际分子量110KD
成分500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol.
纯化方式Affinity-chromatography
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料Phosphatidylinositol-4,5-bisphosphate 3-kinase,also called PIK3CA,is composed of an 85kDa regulatory subunit and a 110kDa catalytic subunit.PIK3CA gene is mapped to 3q26.32.The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate phosphatidylinositols (PtdIns),PtdIns4P andPtdIns(4,5)P2.Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers.It has been found to be oncogenic and has been implicated in cervical cancers.PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy.In addition to that,the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer,indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.
Uniprot IDP42336
推荐稀释比
Western blot (WB) 1:500~2000
Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20~100

相关搜索:PI3 Kinase p110 Alpha/PIK3CA抗体PI3 Kinase p110 Alpha抗体PIK3CA单抗Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody
首页 |  关于我们 |  联系我们 |  在线咨询 |  网站地图
北京百奥莱博科技有限公司 京ICP备14007103号-3