产品货号：
Z36714
中文名称：
PI3 Kinase p110 Alpha/PIK3CA抗体
英文名称：
Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody |
| 指标别名 | p110 alpha;PI3 kinase subunit alpha;PI3K;PI3K alpha;PI3K p110(alpha);PIK3CA;PtdIns 3 kinase subunit alpha |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,ICC/IF |
| 基因名称 | PIK3CA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol),PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns (4,5) P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3).PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane,including AKT1 and PDPK1,activating signaling cascades involved in cell growth,survival,proliferation,motility and morphology.Participates in cellular signaling in response to various growth factors. |
| 实际分子量 | 110KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Phosphatidylinositol-4,5-bisphosphate 3-kinase,also called PIK3CA,is composed of an 85kDa regulatory subunit and a 110kDa catalytic subunit.PIK3CA gene is mapped to 3q26.32.The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate phosphatidylinositols (PtdIns),PtdIns4P andPtdIns(4,5)P2.Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers.It has been found to be oncogenic and has been implicated in cervical cancers.PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy.In addition to that,the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer,indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon. |
| Uniprot ID | P42336 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 |
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